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Title   화학요법제와 Polysaccharide-K 의 병합치료가 위암환자의 Natural Killer Cell 활성도에 미치는 영향 ( Effects of Chemotherapeutic Agents and Polysaccharide-K Combination Therapy on Natural Killer Cell Activitiy in Stomach Cancer Patients )
Publicationinfo   1987 Jan; 019(02): 63-68.
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Abstract   This study was performed to evaluate effects of chemotherapeutic agents and polysaccharide-K combination therapy on natural killer cell activity in 29 patients with inoperable stomach cancer. Of total 29 patienta 9 patients received chemotherapy and krestin and 12 patients received chemotherapy and copolang. In 8 control patiente, only chemotherapy was given. All groups showed the decreasing tendency in NK cell activity after 4 weeks' treatment, but in contrast to control group, krestin and copolang group revealed the inclination to restore NK cell activity after H weeks' treatment. There was significant decrease in peripheral lymphocytes count after 8 weeks treatment. No difference in clinical outcome was found during follow up periods among the groups. We expect that the long-term administration of polysaccharide-K would give beneficial effects on inoperable patients with stomach cancer through the mechanism involving augmentation of NK cell activity.
저 자   정영환(Young Hwan Chung),김창민(Chang Min Kim),이진오(Jhin Oh Lee),강태웅(Taik Koo Yun),조성기(Sung Kee Jo),윤택구(Taik Ku Yun)